Design of a novel class of biphenyl CETP inhibitors

Bioorg Med Chem Lett. 2010 Dec 15;20(24):7469-72. doi: 10.1016/j.bmcl.2010.10.019. Epub 2010 Oct 15.

Abstract

A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.

MeSH terms

  • Animals
  • Benzylamines / chemical synthesis
  • Benzylamines / chemistry*
  • Benzylamines / pharmacology
  • Biphenyl Compounds / chemical synthesis
  • Biphenyl Compounds / chemistry*
  • Biphenyl Compounds / pharmacology
  • Carbamates / chemical synthesis
  • Carbamates / chemistry*
  • Carbamates / pharmacology
  • Cholesterol Ester Transfer Proteins / antagonists & inhibitors*
  • Cholesterol Ester Transfer Proteins / metabolism
  • Disease Models, Animal
  • Drug Design
  • Lipoproteins, HDL / metabolism
  • Mice
  • Mice, Transgenic
  • Structure-Activity Relationship

Substances

  • Benzylamines
  • Biphenyl Compounds
  • Carbamates
  • Cholesterol Ester Transfer Proteins
  • Lipoproteins, HDL
  • diphenyl