Abstract
A new class of CETP inhibitors was designed and prepared. These compounds are potent both in vitro and in vivo. The most active compound (12d) has shown an ability to raise HDL significantly in transgenic mouse PD model.
Copyright © 2010 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Benzylamines / chemical synthesis
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Benzylamines / chemistry*
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Benzylamines / pharmacology
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Biphenyl Compounds / chemical synthesis
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Biphenyl Compounds / chemistry*
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Biphenyl Compounds / pharmacology
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Carbamates / chemical synthesis
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Carbamates / chemistry*
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Carbamates / pharmacology
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Cholesterol Ester Transfer Proteins / antagonists & inhibitors*
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Cholesterol Ester Transfer Proteins / metabolism
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Disease Models, Animal
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Drug Design
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Lipoproteins, HDL / metabolism
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Mice
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Mice, Transgenic
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Structure-Activity Relationship
Substances
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Benzylamines
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Biphenyl Compounds
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Carbamates
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Cholesterol Ester Transfer Proteins
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Lipoproteins, HDL
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diphenyl